发明名称 |
MARKER Lmx1a SPECIFIC TO DOPAMINE-PRODUCING NEURON |
摘要 |
The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for neurodegenerative diseases such as Parkinson's disease, and is useful as a marker for screening agents involved in the induction of dopaminergic neuron differentiation.
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申请公布号 |
EP1712638(A1) |
申请公布日期 |
2006.10.18 |
申请号 |
EP20040819438 |
申请日期 |
2004.11.26 |
申请人 |
EISAI CO., LTD. |
发明人 |
ONO, YUICHI;NAKAGAWA, YASUKO;NAKATANI, TOMOYA |
分类号 |
C12Q1/68;C12Q1/04;G01N33/53;G01N33/68;G01N33/94 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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