发明名称 |
DERIVATIVES OF CEPHALOSPORIN AND CLAVULANIC ACID FOR DETECTING BETA-LACTAMASE IN A SAMPLE |
摘要 |
The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a β-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a β-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a β-lactmase or instructions for using the components in an assay. |
申请公布号 |
EP1711504(A2) |
申请公布日期 |
2006.10.18 |
申请号 |
EP20050711754 |
申请日期 |
2005.01.21 |
申请人 |
MOLECULAR PROBES INC. |
发明人 |
CORRY, SCHUYLER;DOWNEY, WILLIAM;FILANOSKI, BRIAN;GEE, KYLE;GREENFIELD, I., LAWRENCE;HIRSCH, JAMES;JOHNSON, IAIN;RUKAVISHNIKOV, ALEKSEY |
分类号 |
C07D499/00;C07D487/08;C07D501/00;C07D501/14;C07D503/00;C07D519/00;C07F5/02;C09B1/00;C12Q1/18;C12Q1/34 |
主分类号 |
C07D499/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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