| 摘要 |
The present invention dedicates to detect nephritis in early stage of either primary or secondary nephritis using an anti NC1 monoclonal antibody. The present invention dedicates to provide useful information for diagnosis of renal function to detect NC1 by immunofluorescent stain method in renal biopsy section obtained at early stage where immunoglobulins do not deposit yet in renal GBM etc, or by antigen-antibody reaction in urine or serum specimens. Furthermore, the present invention comprises to utilize for therapeutic use. The present invention comprises an anti NC1 monoclonal antibody immunologically responding to NC1 in human and/or animal renal glomeruli. The present invention relates to be able to immunologically stain the patient renal biopsy section by diluting the anti NC1 monoclonal antibody into proper buffer solution and further relates to be able to detect NC1 in serum or urine sample by antigen-antibody reaction. The present invention, furthermore, comprises a sero-cleaning technique for nephritis patient by removal rsf NC1 in the serum using anti NC1 antibody, and/or by removal of anti NC1 antibody in the serum using purified NC1. In addition, the present invention dedicates to prepare a specific anti renal type IV collagen antibody processing by purified renal type IV collagen as an antigen with using the anti NC1 antibody. The anti renal type IV collagen antibody of the present invention can detect renal type IV collagen in urine or serum by antigen-antibody reaction.
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