发明名称 |
ONCE-A-DAY, ORAL, CONTROLLED-RELEASE, OXYCODONE DOSAGE FORMS |
摘要 |
Oxycodone formulations are provided which produce substantially flat in vivo steady state plasma profiles. Tolerance levels associated with such profiles and tolerance levels associated with biphasic profiles are shown not to be statistically different. The substantially flat in vivo steady state plasma profiles are produced by dosage forms having substantially zero order in vitro release profiles. Such release profiles produce low single dose in vivo Cmax levels which can reduce the probability of adverse side effects.
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申请公布号 |
KR20060108690(A) |
申请公布日期 |
2006.10.18 |
申请号 |
KR20067010336 |
申请日期 |
2006.05.26 |
申请人 |
ALZA CORPORATION |
发明人 |
MODI NISHIT B.;SHIVANAND PADMAJA |
分类号 |
A61K31/485;A61K9/00 |
主分类号 |
A61K31/485 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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