| 发明名称 |
Gamma secretase inhibitors |
| 摘要 |
Novel aryl and heteroaryl sulfonamides are disclosed. The sulfonamides, which are gamma secretase inhibitors, are represented by the formula: wherein Ar<SUP>1 </SUP>and Ar<SUP>2 </SUP>independently represent aryl or heteroaryl and Y represents a bond or a -(C(R<SUP>3</SUP>)<SUB>2</SUB>)<SUB>1-3 </SUB>group. Also disclosed is a method of inhibiting gamma secretase, and a method of treating Alzheimer's disease using the compounds of formula I.
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| 申请公布号 |
US7122675(B2) |
申请公布日期 |
2006.10.17 |
| 申请号 |
US20020210803 |
申请日期 |
2002.08.01 |
| 申请人 |
SCHERING CORPORATION |
发明人 |
JOSIEN HUBERT B.;CLADER JOHN W.;ASBEROM THEODROS;PISSARNITSKI DMITRI A. |
| 分类号 |
C07D211/56;A01N43/40;A61K31/40;A61K31/445;A61K31/4462;A61K31/4468;A61K31/453;A61K31/4535;A61K31/454;A61K31/4545;A61K31/4725;A61K31/496;A61K31/506;A61K31/5377;A61K31/54;A61K31/541;A61P25/00;A61P25/28;A61P43/00;C07D207/14;C07D211/58;C07D211/62;C07D211/96;C07D279/00;C07D401/06;C07D401/12;C07D403/06;C07D405/12;C07D409/00;C07D409/06;C07D413/06 |
主分类号 |
C07D211/56 |
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