发明名称 |
Compositions involving M-RIP, and related methods for screening for anti-hypertensive agents, and uses thereof |
摘要 |
The present invention relates to screening methods that make use of Myosin Phosphatase-Rho interacting Protein (M-RIP) for the identification of novel therapeutics for hypertension and hypertensive conditions. Also disclosed are methods for treating or preventing hypertension or hypertensive conditions by administering to a mammal a therapeutically effective amount of an agent that reduces the level or activity of M-RIP. According to this invention, the agent decreases contractile and increases relaxant effects of smooth muscle cells, ultimately decreasing the systemic blood pressure of a mammal. For example, the agent may reduce binding of M-RIP to myosin phosphatase, RhoA, or both.
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申请公布号 |
US7122655(B2) |
申请公布日期 |
2006.10.17 |
申请号 |
US20030715632 |
申请日期 |
2003.11.17 |
申请人 |
NEW ENGLAND MEDICAL CENTER HOSPITAL, INC. |
发明人 |
MENDELSOHN MICHAEL E.;SURKS HOWARD K. |
分类号 |
A61K38/16;A61K38/00;C07H21/04;C07K14/47;C12N9/16;G01N33/68 |
主分类号 |
A61K38/16 |
代理机构 |
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主权项 |
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地址 |
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