发明名称 |
Methods and compositions for identifying receptor effectors |
摘要 |
The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screening of large numbers of polypeptides in a library to identifying those polypeptides which induce or antagonize receptor bioactivity. The subject assay is particularly amenable for identifying surrogate ligands for orphan receptors. |
申请公布号 |
US7122305(B2) |
申请公布日期 |
2006.10.17 |
申请号 |
US20000747774 |
申请日期 |
2000.12.21 |
申请人 |
CADUS TECHNOLOGIES, INC. |
发明人 |
KLEIN CHRISTINE A.;MURPHY ANDREW J.;FOWLKES DANA M.;BROACH JAMES;MANFREDI JOHN;PAUL JEREMY;TRUEHEART JOSHUA |
分类号 |
C12Q1/68;C07K14/395;C12N1/14;C12N1/20;C12N15/81;G01N33/53 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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