发明名称 |
Multiplex method of detecting sequence-specific DNA binding proteins using detection duplexes comprising unmodified nucleic acid sequences as capture tags |
摘要 |
Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput format.
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申请公布号 |
US7122317(B2) |
申请公布日期 |
2006.10.17 |
申请号 |
US20030400670 |
申请日期 |
2003.03.28 |
申请人 |
MARLIGEN BIOSCIENCES, INC. |
发明人 |
CLAUSEN PETER A.;CARLSON DAVID P.;LAZAR JAMES G. |
分类号 |
C12Q1/68;G01N33/50;C12N15/09;C12P19/34;C12Q1/42;C12Q1/44;G01N33/53;G01N33/566;G01N33/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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