发明名称 |
Process for the preparation of epothilone analogs |
摘要 |
The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
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申请公布号 |
USRE39356(E1) |
申请公布日期 |
2006.10.17 |
申请号 |
US20050056606 |
申请日期 |
2005.02.11 |
申请人 |
BRISTOL-MYERS SQUIBB CO. |
发明人 |
LI WEN SEN;THORNTON JOHN E.;GUO ZHENRONG;SWAMINATHAN SHANKAR;BORZILLERI ROBERT M.;KIM SOONG-HOON;FAVREAU DENIS |
分类号 |
C07D491/00;C07D417/00 |
主分类号 |
C07D491/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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