发明名称 |
COMPOSITIONS AND METHODS FOR TREATMENT OF NEOVASCULAR DISEASES |
摘要 |
The present invention provides compositions and methods of treating neovascular diseases, such as a retinal neovascular diseases and tumors, by administering to a patient suffering from a neovascular disease or tumor a vascular development inhibiting amount of a combination of the angiogenesis suppressing drugs comprising an angiostatic fragment of tryptophanyl-tRNA synthetase (TrpRS) and at least one compound selected from the group consisting of a vascular endothelial growth factor (VEGF) signaling inhibitor and an integrin signaling inhibitor. Compositions for use in the methods include an admixture of an angiostatic fragment of tryptophanyl-tRNA synthetase (TrpRS) and at least one of a vascular endothelial growth factor (VEGF) signaling inhibitor and an integrin signaling inhibitor, together with a pharmaceutically acceptable excipient. |
申请公布号 |
WO2005117954(A3) |
申请公布日期 |
2006.10.12 |
申请号 |
WO2005US19800 |
申请日期 |
2005.06.06 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE;FRIEDLANDER, MARTIN;AGUILAR, HILDA EDITH;DORRELL, MICHAEL, I. |
发明人 |
FRIEDLANDER, MARTIN;AGUILAR, HILDA EDITH;DORRELL, MICHAEL, I. |
分类号 |
A61K31/70;A01N43/04;A61K31/538;A61K31/7072;A61K38/19;A61K38/47;A61K38/51;A61K45/06;C07K1/00;C07K14/00;C07K17/00;C12N9/00 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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