AGENTS AND METHODS FOR ENHANCING PHOTODYNAMIC THERAPY

摘要

A chemical conjugate for administration to a patient undergoing photodynamic therapy includes a photoactive compound coupled to a leakage reducing agent that is structured to reduce leakage of the photoactive compound from a patient ' s vasculature . The leakage reducing agent may be a bulking agent to sterically reduce the permeability of the photoactive compound through the blood vessel, or it may be a ligand that binds to endothelial cells of a patient's choriocapillaries . The conjugate may be used in methods of reducing secondary damage associated with photodynamic therapy.