SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS

摘要

This invention relates to novel compounds of the formula (I): wherein W is formula (II) and formula (III); X-Y is -CH<SUB>2</SUB>-O-; CH<SUB>2</SUB>-NH- or -CH<SUB>2</SUB>-CH<SUB>2</SUB>-; R<SUP>16</SUP> is hydrogen, alkyl, haloalkyl or halogen; R<SUP>19</SUP> and R<SUP>20</SUP> are independently hydrogen, halogen or alkyl; R<SUP>27</SUP> and R<SUP>28</SUP> are independently hydrogen, halogen, alkyl, alkoxy or aryl; R<SUP>24</SUP> is hydrogen; R is phenyl or pyridyl; and pharmaceutically acceptable ester or salt, hydrate, solvates thereof. The compounds may be used in the treatment of pathological conditions mediated by a<SUB>v</SUB>ß<SUB>3</SUB> and a<SUB>v</SUB>ß<SUB>5</SUB> integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis.