发明名称 |
Water soluble multi-biotin-containing compounds |
摘要 |
Water-soluble discrete multi-biotin-containing compounds with at least three (3) biotin moieties are disclosed. The water-soluble biotin-containing compounds may additionally comprise one or more moieties that confer resistance to cleavage by biotinidase or that is cleavable in vitro or in vivo. The discrete multi-biotin-containing compounds may include a reactive moiety that provides a site for reaction with yet another moiety, such as a targeting, diagnostic or therapeutic functional moiety. Biotinylation reagents comprising water-soluble linker moieties are also disclosed and may additionally comprise a biotinidase protective group. Methods for amplifying the number of sites for binding biotin-binding proteins at a selected target using multi-biotin compounds also are disclosed.
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申请公布号 |
US2006228325(A1) |
申请公布日期 |
2006.10.12 |
申请号 |
US20060435963 |
申请日期 |
2006.05.17 |
申请人 |
WILBUR D S;PATHARE PRADIP M;HAMLIN DONALD K;WAN FENG |
发明人 |
WILBUR D. S.;PATHARE PRADIP M.;HAMLIN DONALD K.;WAN FENG |
分类号 |
A61K31/765;A61K31/4188;C07D498/02 |
主分类号 |
A61K31/765 |
代理机构 |
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