N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALIN RE-UPTAKE INHIBITORS

摘要

A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein: R¹ is H, C_1-6alkyl, -C(A)Y, C_3-8cycloalkyl, aryl, het, aryl-C_1-4alkyl or het-C_l-4alkyl, wherein the cycloalkyl, aryl or het groups are optionally substituted; A is S or O; Y is H, C_1-6alkyl, aryl, het, aryl-C_1-4alkyl or het­-C_1-4alkyl; aryl is independently selected from phenyl, naphthyl, anthracyl or phenanthryl; het is independently selected from an aromatic or non-aromatic 4-, 5- or 6- membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 5- or 6- membered carbocyclic group or a second 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom; R² is aryl¹ or het¹, each optionally substituted; aryl¹ is independently selected from phenyl, naphthyl, anthracyl, phenanthryl, or indanyl; het¹ is an aromatic 5 to 10 membered heterocyclic ring system which contains at least one N, O or S heteroatom, optionally containing an aryl group; R³ is H, C_1-8alkyl, C_3-8cycloalkyl, C_3-8cycloalkyl-C_1-6alkyl, C_1-8alkylSC_1-8alkyl, het³, or het³-C_1-4alkyl, wherein the alkyl, cycloalkyl and het³ groups are each optionally substituted; het³ is a non-aromatic 4-, 5- or 6- membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 5- or 6- membered carbocyclic group or a second 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom; or R³ is (CH₂)_a