RORalpha PROMOTING EXPRESSION INDUCEMENT OF BMAL1

摘要

PROBLEM TO BE SOLVED: To elucidate unexplained parts of controlling mechanism of circadian rhythm. SOLUTION: Promotion of expression inducement of Bmal1(brain-muscle ARNT-like protein 1) by RORα(retinoic acid receptor-related orphan receptor alpha) and promotion of expression inducement of Bmal1 in low oxygen state are newly found out. Existence of control mechanism of circadian rhythm that promotion of expression of RORαby the low oxygen state or the like promotes expression inducement of Bmal1 and the promotion of expression inducement of Bmal1 promotes bonding of Bmal1 with CLOCK and promotes expression inducement of Per gene or Cry gene, is much suggested thereby. So, application thereof as a jet lag conditioner or an anticancer agent is possible. COPYRIGHT: (C)2007,JPO&INPIT