| 摘要 |
Apparatus is provided for molding and filling a container having a container body defining an opening in communication with an interior chamber for receiving a substance therein, and a stopper receivable within the opening for sealing the opening and substance received in the container. A barrier enclosure defines an aseptic chamber. A mold includes within the aseptic chamber plural mold cavities shaped to form the stopper and container body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the container body and stopper is movable relative to the mold to engage and de-mold the substantially sterile stoppers and container bodies from the mold cavities. A source of sterile air is in fluid communication with the aseptic chamber and directs a flow of sterile air into the aseptic chamber and over the sterile surfaces of the mold for maintaining the sterility of the mold surfaces and stopper and container bodies during de-molding thereof. First flexible barriers are coupled to the mold between the sterile surfaces and the molding machine to substantially prevent the passage of contaminants from the molding machine therethrough. A second flexible barrier is coupled to the tool between the engaging portion and a base portion of the tool to substantially prevent the passage of contaminants from the base portion of the tool therethrough. A needle filling and thermal resealing station is configured to receive the sealed, empty sterile containers, needle fill the interior chambers of the containers, and thermally reseal resulting needle holes in the stoppers.
|
