发明名称 |
A141S AND G399S MUTATION IN THE OMI/HTRA2 PROTEIN IN PARKINSON'S DISEASE |
摘要 |
<p>The present invention relates to a method for diagnosing Parkinson's disease in a human being; nucleic acid molecules used in this method; a nucleic acid molecule which encodes a human Omi/HtrA2 protein which has a genetic modification at amino acid position 141 and/or 399 compared with the wild type, and for corresponding segments thereof; a host, preferably a transgenic non-human mammal, into which such a nucleic acid molecule has been introduced; a (poly)peptide which is encoded by such a nucleic acid molecule; a method for finding substances which bind to Omi/HtrA2 protein which is genetically modified compared with the wild type; a substance found with the aid of this method, and a preferably pharmaceutical composition which comprises such a substance. This invention additionally relates to a kit which comprises at least one of the aforementioned nucleic acid molecules.</p> |
申请公布号 |
EP1709202(A1) |
申请公布日期 |
2006.10.11 |
申请号 |
EP20050701053 |
申请日期 |
2005.01.20 |
申请人 |
EBERHARD-KARLS-UNIVERSITAET TUEBINGEN |
发明人 |
KRUEGER, REJKO;STRAUSS, KARSTEN |
分类号 |
C12Q1/68;A01K67/027;C12N9/64 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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