| 发明名称 |
Substituted 2-(2,6-Dioxo-3-Fluoropiperidine-3-YL)-Isoindolines and their use to reduce TNF-alpha levels |
| 摘要 |
1-Oxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and 1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines reduce the levels of inflammatory cytokines such as TNF alpha in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindoline. |
| 申请公布号 |
EP1710242(A1) |
申请公布日期 |
2006.10.11 |
| 申请号 |
EP20060009666 |
申请日期 |
1998.11.17 |
| 申请人 |
CELGENE CORPORATION |
发明人 |
MULLER, GEORGE W.;STIRLING, DAVID I.;CHEN, ROGER;MAN, HON-WAH |
| 分类号 |
C07D401/04;A61K31/4427;A61K31/4439;A61K31/445;A61K31/452;A61K31/4523;A61P17/06;A61P19/02;A61P29/00;A61P31/08;A61P31/10;A61P33/06;A61P35/00;A61P43/00;C07D |
主分类号 |
C07D401/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
