发明名称 |
A NOVEL PROCESS OF HEPATITIS A VACCINE PREPARATION |
摘要 |
<p>An Indian isolate of Hepatitis A virus- NIVIN97 has been isolated, adapted to tissue culture, characterized and further propagated using Vero and MRC-5 cell lines for vaccine preparation. The method involves the cell culture adaptation of the virus isolate from clinical sample (faecal) in BGMK cell line initially , characterization of the virus and further adaptation to Vero and MRC-5 cells , scale-up ,inactivation and down stream processing method of the inactivated viral antigens for the preparation of an inactivated vaccine.</p> |
申请公布号 |
EP1709162(A2) |
申请公布日期 |
2006.10.11 |
申请号 |
EP20050709163 |
申请日期 |
2005.01.19 |
申请人 |
BHARAT BIOTECH INTERNATIONAL LIMITED;NATIONAL INSTITUTE OF VIROLOGY |
发明人 |
CHITAMBER, SHOBHA;KALANIDHI, AKUNDI |
分类号 |
C12N7/06;A61K39/29;C07K14/10 |
主分类号 |
C12N7/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|