Human monoclonal antibodies to prostate specific membrane antigen

摘要

The invention provides an isolated human monoclonal antibody, or an antigen binding portion thereof, that specifically binds to PSMA, wherein the antibody or antigen binding portion thereof has one or more of the following characteristics:
a) a binding affinity constant to PSMA of at least about 10 7 M -1 ;
b) the ability to opsonize a cell expressing PSMA; or
c) the ability to inhibit growth or to mediate cytolysis of a cell expressing PSMA in the presence of human effector cells at a concentration of about 10 µg/ml or less in vitro .