发明名称 |
THE PREPARATION OF 9-(Z)-RETINOIC ACID |
摘要 |
A process for preparing 9-(Z)-retinoic acid from mother liquors from the industrial preparation of C15-triarylphosphonium salts of the general formula I See Formula I where R1 to R3 are each aryl and X.THETA. is halogen or (HSO4).THETA., in an organic solvent, which comprises A. increasing the proportion of 9-(Z)-C15-triarylphosphonium salt in the C15-triarylphosphonium salts isolated from the mother liquor by treatment with isopropanol at elevated temperature, cooling and separating off the all-(E)-C15-triarylphosphonium salt which has crystallized out, B. subjecting the resulting C15-triarylphosphonium salt to a Wittig reaction with an alkyl .beta.-formylcrotonate of the general formula See Formula II and C. hydrolyzing the resulting oily retinoic ester mixture in a C3-C9-alkanol, preferably in a propanol or butanol, precipitating the resulting 9-(Z)-retinoic acid where appropriate by other adding methanol as crystals, with all-(E)-retinoic acid and retinoic acid isomers remaining in the alkanolic solution.
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申请公布号 |
CA2138882(C) |
申请公布日期 |
2006.10.10 |
申请号 |
CA19942138882 |
申请日期 |
1994.12.22 |
申请人 |
JOHN, MICHAEL;PAUST, JOACHIM |
发明人 |
JOHN, MICHAEL;PAUST, JOACHIM |
分类号 |
C07C403/20;C07C51/00;C07C57/03;C07C69/56;C07C403/00;C07F9/02;C07F9/54 |
主分类号 |
C07C403/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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