Crystalline form gamma of the chlorhydrate of ivabradine, process for its preparation and pharamcetuical composition containing it

摘要

Gamma crystalline form of ivabradine hydrochloride (I) having specific X-ray diffraction profile of: line position (Bragg angle 2 theta, expressed in degrees) of 4.2-29.1; altitude of line (expressed in blows) of 74-2691; surface of line (expressed in blowsxdegrees) of 15-400; width of the lines with mid-height (expressed in degrees) of 0.0836-0.8029; and inter-reticular distance (expressed in Å) of 3.066-20.762 is new. Gamma crystalline form of ivabradine hydrochloride of formula (I) having specific X-ray diffraction profile of: line position (Bragg angle 2 theta, expressed in degrees) of 4.2-29.1; altitude of line (expressed in blows) of 74-2691; surface of line (expressed in blowsxdegrees) of 15-400; width of the lines with mid-height (expressed in degrees) of 0.0836-0.8029; and inter-reticular distance (expressed in Å) of 3.066-20.762 is new. [Image] ACTIVITY : Antiarrhythmic; Cardiant; Antianginal. MECHANISM OF ACTION : None given.