Triazole compounds useful as protein kinase inhibitors

摘要

This invention describes novel triazole compounds of formula IX: wherein Z¹ is nitrogen or CR⁹ and Z² is nitrogen or CH, provided that at least one of Z¹ and Z² is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from -R¹; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R^x and R^y are independently selected from T-R³, or R^x and R^y are taken together with their intervening atoms to form a fused ring; R¹, R³, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3 and Aurora, for treating diseases such as diabetes, cancer, and Alzheimer's disease.