发明名称 |
DNAs encoding guinea pig histamine receptors of the H4 subtype |
摘要 |
DNAs encoding the mammalian histamine H4 receptors have been cloned and characterized. These recombinant molecules are capable of expressing biologically active histamine H4 receptor protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The pharmacology of known histamine ligands is demonstrated. The recombinant protein may be purified from the recombinant host cells. In addition, recombinant host cells are utilized to establish methods to identify modulators of the receptor activity, and receptor modulators are identified.
|
申请公布号 |
US7115395(B2) |
申请公布日期 |
2006.10.03 |
申请号 |
US20030626398 |
申请日期 |
2003.07.23 |
申请人 |
ORTHO-MCNEIL PHARMACEUTICAL, INC. |
发明人 |
LOVENBERG TIMOTHY;LIU CHANGLU |
分类号 |
C12P21/02;G01N33/50;A61K45/00;A61P1/04;A61P1/10;A61P3/10;A61P5/00;A61P9/00;A61P9/06;A61P11/00;A61P11/06;A61P13/08;A61P25/18;A61P29/00;A61P37/08;A61P43/00;C07H21/04;C07K14/705;C07K14/72;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N5/16;C12N15/09;C12N15/12;C12N15/63;G01N33/15 |
主分类号 |
C12P21/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|