摘要 |
The present invention provides compounds having the formula: wherein R<SUP>1</SUP>, R', R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>3'</SUP>, R<SUP>4</SUP>, X<SUP>1</SUP>, X<SUP>2 </SUP>and X<SUP>3 </SUP>are as defined herein, and pharmaceutical compositions thereof. The present invention also provides methods of inhibiting proteases, more specifically aspartyl proteases. In certain embodiments, compounds inhibit BACE (beta-site APP-cleaving enzyme), and thus are useful in the treatment or prevention of a disease characterized by beta-amyloid deposits in the brain (including, but not limited to, Alzheimer's Disease). The present invention also provides methods for preparing compounds of the invention.
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