| 发明名称 |
Thiazole compounds as integrin receptor antagonists derivatives |
| 摘要 |
The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alpha<SUB>v</SUB>beta<SUB>3 </SUB>and/or the alpha<SUB>v</SUB>beta<SUB>5 </SUB>integrin without significantly inhibiting the alpha<SUB>v</SUB>beta<SUB>6 </SUB>integrin.
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| 申请公布号 |
US7115596(B2) |
申请公布日期 |
2006.10.03 |
| 申请号 |
US20030741056 |
申请日期 |
2003.12.19 |
| 申请人 |
PHARMACIA CORPORATION |
发明人 |
WENDT JOHN A.;STENMARK HEATHER;WU HONGWEI;WANG YAPING;CHEN BARBARA B.;PENNING THOMAS D.;DOWNS VICTORIA L.;BOYS MARK L.;RUSSELL MARK;SPANGLER DALE P. |
| 分类号 |
A61K31/55;A61K31/36;A61K31/425;A61K31/44;A61K31/5025;C07D207/00;C07D317/46;C07D401/00;C07D413/00;C07D417/00;C07D417/14;C07D471/02;C07D471/04 |
主分类号 |
A61K31/55 |
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