TREATMENT OF VASCULAR THROMBOSIS AND RESTENOSIS WITH INHALEDNITRIC OXIDE

摘要

Disclosed are methods of treating, inhibiting or preventing vascular thrombosis or arterial restenosis in a mammal. The disclosed methods include causing the mammal to inhale a therapeutically-effective concentration of gaseous nitric oxide (NO). Also disclosed are methods that include the administration of the following types of agents in conjunction with inhaled nitric oxide: compounds that potentiate the beneficial effects of inhaled nitric oxide, and antithrombotic agents th at complement or supplement the beneficial effects of inhaled nitric oxide. The figure is a graph comparing the intima/media ratio in control rats, rats exposed for two weeks to 20 ppm NO, and rats exposed for one week to 80 ppm NO, followed by one week of breathing air. Th e asterisk indicates values significantly differing from baseline (p < 0.05).