发明名称 |
2'-O-Trisubstitueret silyloxymethyl-ribonucleosid-derivat og fremgangsmåde til fremstilling deraf |
摘要 |
<p>The invention provides ribonucleoside derivatives with novel protecting groups and methods for the preparation of such ribonucleoside derivatives. The general formula (I) of the ribonucleoside derivatives is: wherein R<SUB>1 </SUB>is a base of the purine- or pyrimidine-family or a derivative of such a base or any other residue with serves as a nucleobase surrogate, R<SUB>2 </SUB>is a proton or a substituted derivative of phosphonic acid, R<SUB>3 </SUB>is a proton or a protection-group for the oxygen atom in 5'-position, R<SUB>4</SUB>, R<SUB>5 </SUB>and R<SUB>6 </SUB>are independently alkyl or aryl or a combination of alkyl and aryl or heteroatom, R<SUB>4</SUB>, R<SUB>5 </SUB>or R<SUB>6 </SUB>may also be cyclically connected to each other; and wherein at least one of the R<SUB>4</SUB>, R<SUB>5 </SUB>or R<SUB>6 </SUB>substituents comprises a tertiary C-atom or a heteroatom vicinal to the Si-atom.</p> |
申请公布号 |
DK1565479(T3) |
申请公布日期 |
2006.10.02 |
申请号 |
DK20030780024T |
申请日期 |
2003.11.21 |
申请人 |
NOVARTIS AG |
发明人 |
HUNZIKER, JUERG;HALL, JONATHAN;MARTIN, PIERRE;NATT, FRANCOIS, JEAN-CHARLES |
分类号 |
C07H19/00;C07F7/18;C07H21/00 |
主分类号 |
C07H19/00 |
代理机构 |
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