COMPOSITIONS COMPRISING VX478 AND A WATER SOLUBLE TOCOPHEROL DERIVATIVE SUCH AS VITAMIN E-TPGS

摘要

PHARMACEUTICAL FORMULATIONS CONTAINING HIV PROTEASE INHIBITORS, SPECIFICALLY INCLUDING 3S-[3R*(1R*,2S*)]-[[(4-AMINOPHENYL ](2-METHYLPROPYL)-AMINO]-2-HYDROXY-1-PHENYLMETHYL)PROPYL]CARBAMIC ACID, TETRAHYDRO-3-FURANYL ESTER (ALTERNATIVELY KNOWN AS VX 478 OR 141W94), AND A TOCOPHERAL, AND THEIR USE IN MEDICAL THERAPY ARE DESCRIBED.