发明名称 |
SISTEMA TERAPEUTICO TRANSDERMICO TERMOFUNDIVEL PARA ADMINISTRACAO DE ROTIGOTINA |
摘要 |
<p>In a transdermal therapeutic system (TTS) comprising an adhesive matrix containing rotigotine (A) as active agent, the matrix is a hot-meltable contact adhesive. Independent claims are included for: (1) a TTS for continuous delivery of (A), which induces an average plasma (A) concentration of 0.4-2 ng/ml over a period of at least 5 days on application to human skin or transports (A) through the skin at a steady-state flux rate of 200-300 mu g/h over a period of at least 5 days; and (2) the production of a TTS including an adhesive matrix containing (A), by melting and homogenizing the components of the matrix at 70-200 (preferably 120-180)[deg]C (preferably in an extruder) before lamination. ACTIVITY : Antiparkinsonian; Muscular-Gen. MECHANISM OF ACTION : Dopamine agonist.</p> |
申请公布号 |
PT1492517(E) |
申请公布日期 |
2006.09.29 |
申请号 |
PT20030750403T |
申请日期 |
2003.07.29 |
申请人 |
SCHWARZ PHARMA AG |
发明人 |
BREITENBACH, ARMIN;WOLFF, HANS-MICHAEL |
分类号 |
A61K9/70;A61K31/381;(IPC1-7):A61K9/70 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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