Method of modulating growth differentiation factor (GDF) signal transduction in a muscle or adipose tissue cell to treat wasting disorders

摘要

A transgenic non human animal whose genome contains a nucleic acid sequence comprising a truncated Activin Type II receptor gene and a muscle-specific promoter operably linked and integrated into the genome of the animal. The nucleic acid sequence is expressed so as to result in elevated levels of truncated Activin Type II receptor and increased muscle mass in the animal as compared to a corresponding nontransgenic animal.