Heterocyclic inhibitors of ERK2 and uses thereof

摘要

Disclosed is the use of a compound of formula I for the manufacture of a medicament for inhibiting ERK-2 activity, wherein: Sp is a 5-membered heteroaromatic ring, wherein Ring A and QR2 are attached to Sp at non-adjacent positions, and wherein Sp has up to two R6 substituents, provided that two substitutable carbon ring atoms in Sp are not simultaneously substituted by R6, Z1 and Z2 are each independently selected from N or CH, each of T and W is independently, an optionally substituted saturated or unsaturated alkylidene chain, wherein up to 2 saturated carbons of the chain are replaced by -CO-, -C(O)C(O)-, -C(O)NR7-, -C(O)NR7NR7-, -CO2-, -OC(O)-, -NR7CO2-, -O-, -NR7C(O)NR7-, -OC(O)NR7-, -N(R7)N(R7)-, -NR7C(O)-, -S-, -S(O)-, -S(O)2-, -NR7-, -SO2NR7-, or -NR7SO2-, and the remaining substituents are defined herein.