发明名称 |
Oligosaccharide biomarkers for mucopolysaccharidoses and other related disorders |
摘要 |
Methods for diagnosing mucopolysaccharidoses ("MPS") and related diseases. This invention pertains to methods for identifying and quantitating biochemical markers ("biomarkers") that are present in biological fluids or tissues of a patient having a MPS or related disorder. One aspect of the method comprises determining a target quantity of a target MPS biomarker oligosaccharide from a target biological sample taken from the target animal, and then comparing the target quantity to a reference quantity of a reference MPS biomarker oligosaccharide for the diagnosis, characterization, monitoring , and clinical management of MPS and related disease. This invention also describes a kit comprising a oligosaccharide derivatization solution; an acid solution; an internal standard; a solid phase extraction column; a solid phase extraction column wash solution; an oligosaccharide elution solution; and a set of instructions for using the kit to diagnose a MPS or related disease.
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申请公布号 |
NZ537512(A) |
申请公布日期 |
2006.09.29 |
申请号 |
NZ20030537512 |
申请日期 |
2003.06.13 |
申请人 |
WOMEN'S AND CHILDREN'S HOSPITAL |
发明人 |
MEIKLE, PETER JOHN;FULLER, MARIA;RAMSEY, STEVE LEWIS;RANIERI, ENZO;HOPWOOD, JOHN JOSEPH |
分类号 |
G01N33/50;C12Q1/34;C12Q1/527;G01N30/26;G01N30/88;G01N33/48;G01N33/53;G01N33/66;(IPC1-7):G01N33/48 |
主分类号 |
G01N33/50 |
代理机构 |
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主权项 |
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地址 |
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