Method of separating unattached Raman-active tag from bioassay or other reaction mixture

摘要

A super-paramagnetic Raman-active complex that includes a Raman-active tag attached to a target and a super-paramagnetic bead attached to the target is disclosed. A method of separating a Raman or surface enhanced Raman-active tag unattached to a target from a Raman-active complex is also disclosed. The Raman-active complex includes a Raman-active tag attached to a target. The method includes providing a mixture that includes at least one Raman-active tag unattached to a target and at least one super-paramagnetic Raman-active complex; and applying a magnetic field to the mixture.