发明名称 |
FUSION PROTEINS COMPRISING A NON-CYTOTOXIC PROTEASE, A TARGETING MOIETY, A PROTEASE CLEAVAGE SITE AND A TRANSLOCATION DOMAIN |
摘要 |
The invention provides a single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a target cell; a Targeting Moiety that is capable of binding to a Binding Site on the target cell, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the target cell; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease or fragment thereof and the Targeting Moiety; and a translocation domain that is capable of translocating the protease or protease fragment from within an endosome, across the endosomal membrane and into the cytosol of the target cell. |
申请公布号 |
WO2006059113(A3) |
申请公布日期 |
2006.09.28 |
申请号 |
WO2005GB04606 |
申请日期 |
2005.12.01 |
申请人 |
HEALTH PROTECTION AGENCY;FOSTER, KEITH;CHADDOCK, JOHN;MARKS, PHILIP;STANCOMBE, PATRICK;DUROSE, LYNDSEY |
发明人 |
FOSTER, KEITH;CHADDOCK, JOHN;MARKS, PHILIP;STANCOMBE, PATRICK;DUROSE, LYNDSEY |
分类号 |
C07K14/33;A61K38/00;C12N15/62 |
主分类号 |
C07K14/33 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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