ANTI-CANCER AGENT AND BACTERIUM CAPABLE OF PRODUCING NOVEL COMPOUND PRUNUSTATIN

摘要

[PROBLEMS] To search a substance capable of inhibiting the induction of the expression of GRP78 to find a novel anti-cancer agent. [MEANS FOR SOLVING PROBLEMS] A novel compound represented by the chemical formula 1 is now found as a substance capable of inhibiting the induction of the expression of GRP78 and named "prunustatin". Prunustatin has a structure similar to that of a known compound SW-163A and can be produced by Streptomyces Violaceoniger strain 4521-SVS3 or the like. A pharmaceutical composition comprising at least the compound is likely to be effective as an anti-cancer agent.