| 摘要 |
A chemical composition; comprising one or more carotenoid analogs or derivatives having a structure (I), (II) and (III) where each R3 is independently hydrogen or methyl, and where each R1 and R2 are independently wherein each R5 is independently hydrogen, -OH, or -OR6, wherein at least one R5 group is -OR6; wherein each R6 is independently: alkyl; aryl; -alkyl- N(R7)2; -aryl-N(R7)2; -alkyl-N+ (R7)3; -aryl-N+(R7)3; -alkyl-CO2R7; -aryl- CO2R7; -alkyl-CO2; -aryl-CO2; -CO2R8; -P(O)(OR8)2; -S(O)(OR8)2; an amino acid; a peptide, a carbohydrate; -C(O)- (CH2)0-CO2R9; a nucleoside residue, or a co- antioxidant; wherein R7 is hydrogen, alkyl, or aryl; wherein R8 is hydrogen, alkyl, aryl, benzyl or a co-antioxidant; wherein R9 is hydrogen; alkyl; aryl; - P(0)(OR8)2; -S(0)(OR8)2; an amino acid; a peptide, a carbohydrate; a nucleoside, or a co-antioxidant; and wherein n is 1 to 9. The compounds are useful for the inhibition and amelioration of diseases resulting in change and/or loss of vision.
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