METHOD OF PRODUCING 3-HYDROXYBUTYRALDEHYDE DERIVATIVE

摘要

A method of producing a 3-hydroxybutyraldehyde derivative, in particular, an optically active 3-hydroxybutyraldehyde derivative which is useful as an intermediate of drugs, etc. Namely, a method characterized by comprising converting a 3-hydroxybutyrate derivative into an alcohol derivative by a reduction reaction and then deriving it into the desired aldehyde derivative by an oxidation reaction with the use of a nitroxyl compound and a cooxidant. Thus, a 3-hydroxybutyraldehyde derivative having high qualities (containing only a small amount of a low alcohol derivative) can be produced by a convenient method without resorting to a reaction under an extremely low temperature conditions.