Recombinant antibodies and compositions and methods for making and using the same

摘要

Methods and compositions are provided for the use of rabies virusneutralizing antibodies for postexposure prophylactic treatment of subjects exposed to rabies virus. Compositions comprising mixtures of rabies virusneutralizing antibodies, as well as nucleotide and amino acid sequences encoding these antibodies, can be used in the treatment of subjects exposed to rabies virus. The invention also provides methods of producing recombinant rabies virus-neutralizing human antibodies in mammalian cells using recombinant expression vectors.