| 摘要 |
<p>Wire guide devices, and methods (300) of using same, having an elongate shaft (10, 110) with a first end portion (14, 114) and a flexible second end portion (16,116) having a non-coiled portion (24, 124) comprising a nominal outer circumference (22, 122) disposed about a longitudinal axis (18, 118) and having a first outer surface (12, 112) including the nominal outer circumference( 22, 122) and defining a first surface area (30, 130). Textures such as protuberances (26), indentations (28), peaks (160), and/or valleys (161) are disposed substantially circumferentially about the nominal outer circumference (22, 122) and defining an effective perimeter (21, 121) greater than the nominal outer circumference (22, 122) and having a second outer surface (20, 120) defining a second surface area (40, 140) greater than the first surface area (30, 130). Hydrophilic materials and therapeutic agents may be disposed partially on the second end portion (24, 124) and a coating (54, 74), and a membrane 84 may be disposed about non-coiled portion (24, 124) and coating (54, 74) to form reservoirs (73) or lumens (76) for delivering hydrophilic materials and delivering therapeutic agents.</p> |
