USE OF AN INFLUENZA VIRUS AN OIL-IN-WATER EMULSION ADJUVANT TO INDUCE CD4 T-CELL AND/OR IMPROVED B-MEMORY CELL RESPONSE

摘要

The present invention relates to influenza vaccine formulations and vaccination regimes for immunising against influenza disease. In particular the invention relates to vaccine formulations comprising an oil-in-water emulsion adjuvant and optionally 3D-MPL, their use in medicine, in particular their use in augmenting immune responses to influenza antigens, and to methods of preparation, wherein the oil in water emulsion comprises a sterol, a metabolisable oil and an emulsifying agent.