TARGETED ADENOVIRAL VECTOR DISPLAYING IMMUNOGLOBULIN-BINDING DOMAIN AND USES THEREOF
摘要
The present invention provides a targeted recombinant adenovirus vector expressing a fiber protein modified by insertion of an immunoglobulin-binding domain that can crosslink to a fusion protein comprising a targeting ligand and an immunoglobulin Zc domain. Interaction between the immunoglobulin-binding domain and the Zc domain results in a targeted vector::ligand complex, thereby targeting the adenovirus vector to a cell that expresses a cell surface molecule that binds to said targeting ligand.
申请公布号
WO2006085913(A3)
申请公布日期
2006.09.28
申请号
WO2005US19739
申请日期
2005.06.03
申请人
VECTORLOGICS, INC.;EMD LEXIGEN RESEARCH CENTER CORP.;KOROKHOV, NIKOLAY;BOUREDDINI, SAM, C.