MONITORING AND TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

摘要

The invention provides methods of monitoring amyotrophic lateral sclerosis (ALS) disease development or progression and monitoring an ALS therapy in an individual by determining the presence or absence of Herv-K/HML-2 expression in a biological sample from the individual. The invention is also directed to methods for aiding diagnosis of ALS by determining expression of Herv-K/HML-2 in a biological sample from the individual. The invention is also directed to methods of reducing Herv-K/HML-2 expression in infected cells and individuals. The invention includes reagents for use in these methods.