摘要 |
<p>Disclosed are materials and methods for preparing optically active ß-amino acids, which bind to the alpha-2-delta subunit of a calcium channel and are useful for treating pain, fibromyalgia, and a variety of psychiatric and sleep disorders. The method includes reacting a chiral allyl amine with a 2-alkynoate in the presence of a Lewis acid and a base to give a chiral tertiary enamine, which after reaction with ammonia, is hydrogenated to give optically active ß-amino acids.</p> |
申请人 |
PHARMACIA & UPJOHN COMPANY LLC;FRANCZYK, THADDEUS, STEPHAN, II;HERRINTON, PAUL, MATTHEW;PERRAULT, WILLIAM, ROLAND |
发明人 |
FRANCZYK, THADDEUS, STEPHAN, II;HERRINTON, PAUL, MATTHEW;PERRAULT, WILLIAM, ROLAND |