发明名称 |
POLYENE ANTIBIOTICS, COMPOSITIONS CONTAINING SAID ANTIBIOTICS, METHOD AND MICRO-ORGANISMS USED TO OBTAIN SAME AND APPLICATIONS THEREOF |
摘要 |
Abstract: The invention relates to novel polyenes having formula (I), wherein: R1 represents alkyl C 1 -C 3 ; and R2 represents a functional group selected from CH 3 - or CONH 2 - (methyl- or primary amide-). The aforementioned polyenes have a biocide action on organisms comprising cell membranes that contain ergosterol, e.g., fungi or parasites. Said compounds can be obtained using a method that consists in cultivating a producing micro-organism under conditions that enable the production thereof. In addition, the invention also relates to a mechanism for the in vitro production of amidated polyenes, consisting in incubating carboxylated polyenes with cell-free extracts (or proteinaceous fractions) of the producers of same in the presence of ATP/Mg ++ and an amide-group donor compound (preferably glutamine). |
申请公布号 |
CA2602355(A1) |
申请公布日期 |
2006.09.28 |
申请号 |
CA20062602355 |
申请日期 |
2006.03.23 |
申请人 |
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS |
发明人 |
MALPARTIDA ROMERO, FRANCISCO;SECO MARTIN, ELENA MARIA;CUESTA VELASCO, TRINIDAD |
分类号 |
C07H17/08;A61P31/00;C12P19/62 |
主分类号 |
C07H17/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|