2-THIO-SUBSTITUTED DERIVATIVES OF IMIDAZOLE, THEIR USING AND PHARMACEUTICAL AGENT BASED ON THEREOF

摘要

FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to 2-thio-substituted derivatives of imidazole of the formula (I) , their optical isomers and physiologically acceptable salts wherein R1, R2, R3 and R4 have values given in claim 1 of the invention. Compounds possess immunomodulating and/or inhibitory effect on cytokine release and can be useful in treatment of diseases associated with the immune system disorder. Also, invention relates to a pharmaceutical agent inhibiting release of cytokines based on compounds of the formula (I) and using these compounds for preparing a pharmaceutical agent inhibiting release of cytokines for treatment of diseases associated with the immune system disorder. ^ EFFECT: valuable medicinal properties of compounds and pharmaceutical composition. ^ 13 cl, 1 tbl, 88 ex