发明名称 |
USE OF CRIPTO-1 AS A BIOMARKER FOR NEURODEGENERATIVE DISEASE AND METHOD OF INHIBITING PROGRESSION THEREOF |
摘要 |
A method of detecting a neurodegenerative disease in a mammal, which method comprises assaying the copy number of a Cripto-1 gene or the expression level of a Cripto-1 gene product in the central nervous system of the mammal, wherein an amplification of the Cripto-1 gene or an overexpression of the Cripto-1 gene product is indicative of a neurodegenerative disease in the mammal; a method of inhibiting progression of a neurodegenerative disease in a mammal, which method comprises administering to the mammal an agent that inhibits Cripto-1 in an amount effective to inhibit Cripto-1 in the central nervous system of the mammal, whereupon the progression of the neurodegenerative disease is inhibited; and an isolated or purified oligonucleotide consisting essentially of the sequence of AAGCTATGGACTGCAGGAAGATGG (SEQ ID NO: 3) or AGAAGGCAGATGCCACTAGC (SEQ ID NO: 4). |
申请公布号 |
EP1704247(A2) |
申请公布日期 |
2006.09.27 |
申请号 |
EP20040794121 |
申请日期 |
2004.10.01 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;UNIVERSITY OF KANSAS MEDICAL CENTER |
发明人 |
SALOMON, DAVID;BERMAN, NANCY;STEPHENS, EDWARD |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|