发明名称 |
Androgen receptor-dependent gene expression control by inhibiting the amine oxidase activity of lysine-specific demethylase (LSD1) |
摘要 |
The invention relates to the use of at least one amine oxidase inhibitor for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal and to pharmaceutical compositions for controlling the androgen receptor-dependent gene expression, comprising an effective dose of at least one amine oxidase inhibitor suitable for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal. The invention also relates to assay systems allowing to test LSD1 inhibitors for their ability to inhibit LSD1 function. |
申请公布号 |
EP1704859(A1) |
申请公布日期 |
2006.09.27 |
申请号 |
EP20050003596 |
申请日期 |
2005.02.18 |
申请人 |
UNIVERSITAETSKLINIKUM FREIBURG |
发明人 |
SCHUELE, ROLAND PROF.;METZGER, ERIC DR. |
分类号 |
A61K31/137;A61K31/7088;C12Q1/26;C12Q1/48 |
主分类号 |
A61K31/137 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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