发明名称 |
OLIGONUCLEOTIDE COMPOUND AND METHOD FOR TREATING NIDOVIRUS INFECTIONS |
摘要 |
<p>A method and oligonucleotide compound for inhibiting replication of a nidovirus in virus-infected animal cells are disclosed. The compound (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the infected cells, (iii) contains between 8-25 nucleotide bases, and (iv) has a sequence capable of disrupting base pairing between the transcriptional regulatory sequences in the 5′leader region of the positive-strand viral genome and negative-strand 3′subgenomic region. In practicing the method, infected cells are exposed to the compound in an amount effective to inhibit viral replication.</p> |
申请公布号 |
EP1704243(A2) |
申请公布日期 |
2006.09.27 |
申请号 |
EP20040815419 |
申请日期 |
2004.12.23 |
申请人 |
AVI BIOPHARMA, INC. |
发明人 |
STEIN, DAVID, A.;BESTWICK, RICHARD, K.;IVERSEN, PATRICK, L.;NEUMAN, BENJAMIN;BUCHMEIER, MICHAEL |
分类号 |
C12Q1/00;A01N57/00;A61K31/685;A61K48/00;C07F9/6533;C07H21/02;C07K14/165;C12N15/113 |
主分类号 |
C12Q1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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