Selective androgen receptor modulators and methods of use thereof

摘要

This invention provides a selective androgen receptor modulator compound having in-vivo androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor, the selective androgen receptor modulator compound represented by the structure of formula II below,
wherein X is O;
Z is a hydrogen bond acceptor, NO 2 , CN, COR, CONHR;
Y is a lipid soluble group, I, CF 3 , Br, Cl, SnR 3 ;
R is an alkyl or aryl group or HO; and
Q is acetamido, trifluoracetamido, alkylamines, ether, alkyl, N-sulfonyl, O-sulfonyl, alkylsulfonyl, carbonyl or a ketone.
The agents are useful for hormone therapy and for treating prostate cancer.